VIM, vimentin, 7431

N. diseases: 644; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014145
Disease: Yolk Sac Tumor
Yolk Sac Tumor
0.010 Biomarker disease BEFREE Vimentin (p < 0.001) and Zeb1 (p = 0.029) staining was significantly higher in immature teratomas compared with yolk sac tumors and dysgerminomas, whereas no significant differences were observed for N-cadherin and P-cadherin. 28585395 2017
CUI: C0410203
Disease: X-linked centronuclear myopathy
X-linked centronuclear myopathy
0.010 Biomarker disease BEFREE Expression patterns of the intermediate filament proteins (IFPs) desmin and vimentin, in biopsy material taken from a 1 day old boy with fatal neonatal X-linked myotubular myopathy (XLMTM) were compared with the expression of these proteins in cultured myotubes, from the same patient. 7580238 1995
Well Differentiated Oligodendroglioma
0.010 Biomarker disease BEFREE All tumors had GFAP-positive neoplastic cells and vimentin was also found in all the tumors except one oligodendroglioma. 7518371 1994
CUI: C0043094
Disease: Weight Gain
Weight Gain
0.300 Biomarker phenotype CTD_human Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice. 19030233 2008
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.020 Biomarker group BEFREE These findings are the first to demonstrate that vimentin is critical for influenza viral infection as it facilitates endosomal trafficking and acidification, and mediates viral genome penetration into the cytoplasm to propagate the infection. 27423069 2016
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.020 Biomarker group BEFREE Vimentin is a part of the cytoskeleton network and plays an important role in several virus infections. 29079448 2018
CUI: C0947751
Disease: Vascular inflammations
Vascular inflammations
0.010 Biomarker phenotype BEFREE We demonstrate that vimentin has a strong suppressive effect on oxidative stress and that Vim<sup>-/-</sup> mice display increased vascular inflammation with increased CD36 expression on macrophages despite decreased subendothelial lipid accumulation. 30451917 2018
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases
0.010 Biomarker group BEFREE Exosomes isolated from heart transplant recipients diagnosed with coronary artery vasculopathy had a 3.9-fold increase in myosin and a 4.7-fold increase in vimentin compared with stable. 29908844 2018
CUI: C0042345
Disease: Varicosity
Varicosity
0.010 AlteredExpression disease BEFREE In varicose veins and proliferative VSMCs, miR-202 expression was upregulated, with decreased SM-22α expression and increased vimentin and collagen I expression. 30556158 2019
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma
0.010 Biomarker disease BEFREE Our data demonstrate that human uveal melanoma cell lines (isolated from primary choroidal or ciliary body melanomas and from foci of metastatic uveal melanoma to the liver), which contain predominant populations of cells that coexpress vimentin/keratins 8 and 18 (keratins 8,18) IFs, were 6-fold more invasive through collagenous extracellular matrices in vitro, compared with uveal melanoma cells expressing vimentin only, and were 8- to 13-fold more invasive than normal uveal melanocytes. 9484713 1998
CUI: C0042133
Disease: Uterine Fibroids
Uterine Fibroids
0.010 Biomarker group BEFREE Using a tissue microarray technique (TMA), cases of myofibroma (MF), of nodular fasciitis (NF), of desmoplastic fibroma (DF), and of myofibroblastic sarcoma (MS) from the Universidad Autónoma Metropolitana Xochimilco, and a Private Oral Pathology Service in Mexico City were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, CD34, anaplastic lymphoma protein kinase (ALK-1), and Ki-67. 30168888 2019
Uterine Corpus High Grade Endometrial Stromal Sarcoma
0.010 Biomarker disease BEFREE The low-grade ESS expressed hormonal receptors and vimentin, whereas the high-grade ESS showed no hormone receptors, high Ki-67 activity, and occasional cytokeratin-positive cells. 10335941 1999
CUI: C2145472
Disease: Urothelial Carcinoma
Urothelial Carcinoma
0.010 GeneticVariation disease BEFREE Urothelial carcinoma was found in 3/9 (30%) of vimentin negative cases. 27888661 2017
CUI: C0042035
Disease: Urination Disorders
Urination Disorders
0.200 Biomarker group RGD Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats. 21250919 2011
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection
0.010 Biomarker group BEFREE Prevalence of VIM- and GIM-producing Acinetobacter baumannii from patients with severe urinary tract infection. 30111160 2018
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction
0.050 AlteredExpression phenotype BEFREE We showed that MRPECs underwent EndoMT after rhTGF-β1 treatment or in UUO kidney as evidenced by decreased expression of endothelial markers, vascular endothelial cadherin (VE-cadherin) and CD31, and increased levels of mesenchymal markers, α-smooth muscle actin (α-SMA) and vimentin. 27566305 2017
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction
0.050 Biomarker phenotype BEFREE Lower expressions of transforming growth factor (TGF)-β1, α-smooth muscle actin (α-SMA), fibronectin, vimentin, and phospho-Smad2/3 were observed in kidney of Elp2-KO mice than that of WT mice after UUO. 29723529 2018
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction
0.050 AlteredExpression phenotype BEFREE SIS3 treatment also suppressed the activation of myofibroblasts, as evidenced by decreased expression levels of a-SMA and vimentin in UUO kidneys. 29555895 2018
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction
0.050 Biomarker phenotype BEFREE Further investigation 3 days after UUO showed a significant increase of Col1a1 and vimentin in Angpt1 deficient mice, as well as increased gene expression of Tgfb1, Col1a1, Fn1, and CD44. 29293543 2018
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction
0.050 Biomarker phenotype BEFREE The abnormal expression of epithelial-mesenchymal transition (EMT)-related proteins including vimentin, α-SMA and β-catenin was also significantly decreased in rats with transplantation of TUG891-programmed macrophages as compared to UUO rats. 31261028 2019
Undifferentiated carcinoma of nasopharynx
0.010 Biomarker disease BEFREE The aim of this study was to investigate the expression of intermediate filaments (cytokeratin, vimentin), epithelial membrane antigen (EMA) and the presence of Epstein-Barr virus (EBV) DNA in undifferentiated nasopharyngeal carcinoma (NPC). 11326639 2001
Undifferentiated (Embryonal) Sarcoma
0.010 AlteredExpression disease BEFREE Undifferentiated sarcoma expressed only vimentin. 12110339 2002
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.010 Biomarker disease BEFREE In non-inflamed UC (QUC) keratins, vimentin, and focal adhesion kinase (7) increased, whereas vinculin and de-tyrosinated α-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being collagen type VI alpha 1 chain (COL6A1), tenascin-C and vimentin increased. 29027377 2017
CUI: C4049272
Disease: Tumour budding
Tumour budding
0.020 AlteredExpression disease BEFREE The association of tumor budding with vimentin expression supported the idea that EMT is a key process in PDAC responsible for progression and drug resistance. 29233500 2018
CUI: C4049272
Disease: Tumour budding
Tumour budding
0.020 PosttranslationalModification disease BEFREE This study found that TBs exhibit characteristics of partial EMT with a decreased expression of E-cadherin and no substantial differences in the expression of N-cadherin and vimentin. 31676872 2020